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01 Free Resource · The Handbook
Pathology handbook · Plain-language test guide

The pathology handbook.

Every blood test, swab and biopsy result you have ever received started in a pathology laboratory. This handbook explains the tests most commonly requested in Australian practice, what they measure, why your doctor orders them, and the reference ranges that put your results in context.

Plain-language guide Reference ranges included RCPA aligned Free to read
Standard RCPA Manual aligned
Audience Patients & families
Ranges Indicative, lab-verified

10tests

explained in plain language

5groups

from full blood count to swabs

1rule

a range is context, not a verdict

100% free

no account, no paywall
Why this handbook exists

A result you can read is a result you can use. Plain language turns anxious waiting into informed conversation.

Tricorian Life
02 How Pathology Works
The laboratory behind your results

From your arm to your results.

A pathologist is a specialist doctor who studies disease through laboratory science. When your GP orders a test, a sample is collected, processed in a laboratory, and interpreted by a pathologist who issues the report your doctor uses to make decisions.

01

Request

Your GP or specialist orders the test with a specific clinical question in mind.

02

Collect

Blood, urine, swab or tissue is collected at a collection centre or in hospital.

03

Analyse

The laboratory runs the requested tests using standardised, quality-controlled methods.

04

Interpret

A pathologist reviews the findings and writes a report, flagging anything important.

05

Report

Results return to your doctor, who interprets them in the context of you as a person.

03 Reference Ranges
The most important concept

A reference range is context, not a verdict.

A reference range is the interval of results seen in healthy people. It is built by testing a large healthy population and taking the central 95 percent of results. That has real consequences for how you should read your report.

5 percent of healthy people sit outside

By definition, about 1 in 20 healthy people has a result outside the range on any given test. A single borderline result is usually rechecked, not acted on.

Ranges vary between laboratories

Each laboratory validates its own ranges for its own equipment and population. That is why the same test can show slightly different ranges on reports from different labs. Always read the range printed on your own report.

Age and sex change the range

Many ranges differ by age and sex. Haemoglobin, for example, has different ranges for men and women, and children have their own entirely.

Trend matters more than one value

Your own history is the most powerful reference range of all. A value moving over time often tells your doctor more than a single snapshot.

The ranges in this handbook are indicative adult ranges for educational purposes, drawn from common Australian laboratory practice. Your own laboratory's printed reference range, on your own report, is always the one that applies. For the definitive Australian standard, see the RCPA Manual, Pathology Tests A-Z.

04 The Tests
Most commonly requested

Ten tests, explained properly.

Each card covers what the test measures, why it is ordered, and the indicative adult range. Where a test links to a disease guide or glossary term, it is cross-linked so the whole education library connects.

Full blood count (FBC)

Counts your red cells, white cells and platelets. Screens for anaemia, infection, inflammation and clotting problems, and is one of the most ordered tests in medicine.

Key parts: Haemoglobin 130–175 g/L (men), 115–160 g/L (women) · White cell count 4.0–11.0 x10&sup9;/L · Platelets 150–400 x10&sup9;/L

C-reactive protein (CRP)

A marker of inflammation in the body. Rises quickly with infection and inflammatory conditions, and falls as you recover, which makes it excellent for monitoring treatment.

Range: < 5 mg/L. Mild elevations occur with colds and injury; high levels point to significant infection or inflammation.

Urea, electrolytes & creatinine (UEC)

Assesses kidney function and your salt and water balance. Ordered routinely, before imaging with contrast, and to monitor many medications.

Key parts: Creatinine 60–110 µmol/L (men), 45–90 µmol/L (women) · Sodium 135–145 mmol/L · Potassium 3.5–5.2 mmol/L

Liver function tests (LFT)

A panel assessing the liver's enzymes, protein production and bilirubin handling. Ordered to investigate symptoms, monitor medications and screen for liver disease.

Key parts: ALT 5–40 U/L · AST 5–40 U/L · ALP 30–110 U/L · Bilirubin < 20 µmol/L

Lipid profile

Measures cholesterol and triglycerides to estimate cardiovascular risk. The target values depend on your overall risk, so your doctor interprets them in context.

Key parts: Total cholesterol < 5.5 mmol/L · LDL < 2.0 mmol/L (high risk targets lower) · HDL > 1.0 mmol/L

Thyroid stimulating hormone (TSH)

The pituitary's signal to the thyroid. The single best screening test for overactive or underactive thyroid, and how thyroid medication is monitored.

Range: 0.4–4.0 mIU/L. Values outside this prompt further thyroid testing.

HbA1c

Estimates your average blood glucose over the previous two to three months. Used to diagnose diabetes and to monitor how well glucose is controlled.

Range: < 6.0% normal · 6.0–6.4% at risk · ≥ 6.5% diagnostic of diabetes on repeat testing

Iron studies

Assesses iron stores and how your body transports iron. Ordered for fatigue, suspected anaemia or iron overload.

Key parts: Ferritin 30–300 µg/L (men), 15–200 µg/L (women) · Transferrin saturation 15–50%

Wound swab: microscopy, culture & sensitivity (MC&S)

A swab from a wound is examined for organisms, cultured to identify the exact bacteria, and tested against antibiotics to find which will work. Central to managing surgical site infections.

Result: Identifies the organism and lists which antibiotics it is sensitive to.

Histopathology

Tissue from a biopsy or surgery is examined under the microscope. The report describes the cells, confirms diagnoses including cancer, and grades how aggressive a tumour appears.

Result: A written diagnosis and description, not a number. Read with your treating doctor.

For the complete, laboratory-authoritative reference for any test, use the RCPA Manual, Pathology Tests A-Z, the standard reference used by Australian clinicians.

05 Reading Your Report
Practical skills

How to read your own results page.

Find the reference range firstIt is printed next to your result. Compare your value to that range, not to a range from memory or another lab.
Read the flags, but calmlyH for high and L for low mark values outside the range. Remember that about 1 in 20 healthy results sits outside.
Look for the pathologist's commentMany reports carry a written interpretation. That comment is the most valuable line on the page.
Compare with your own historyYour previous results are the best baseline. Trends matter more than isolated values.
Bring questions to your doctorWrite down what confused you and ask at your next appointment. Results are meant to be discussed, not decoded alone.
Do not self-diagnosePatterns matter, and only your treating team has your full clinical picture. This handbook supports the conversation, it does not replace it.
06 Common Questions
Frequently asked

Questions patients ask about their results.

Why is my result flagged when I feel completely fine?

Because reference ranges are statistical, not judgemental. Roughly 1 in 20 healthy people falls outside on any given test, and everyday factors like recent exercise, fasting state and hydration can nudge values. Your doctor weighs the number against how you actually are, which is why results are always read in context.

How long do pathology results take?

Most routine blood results return within 24 to 48 hours. Cultures grow over several days because bacteria need time to multiply. Histopathology takes several days to weeks because tissue must be processed, stained and examined. Your requesting doctor or the collection centre can tell you the expected timing for your specific test.

Do I need to fast before a blood test?

Some tests, such as fasting glucose and certain lipid profiles, require fasting. Many modern tests do not. Always follow the specific instructions given when your test was booked, and ask if you are unsure.

Where can I find the official Australian reference?

The RCPA Manual is the standard Australian reference for pathology testing. Its Pathology Tests A-Z lists tests with their purpose, method and reference intervals as used by Australian laboratories, and is freely available at rcpa.edu.au.

Reach out

Confused by a result?

If you need a recommendation or guidance in this space, whether understanding a report, deciding between tests, or knowing what to ask your doctor next, reach out and our team will help. We respond within 24 hours.

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